Captopril-Disuphide , 64806-05-9

Synonym(s):
(2S)-1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]pyrrolidine-2-carboxylic acid;N-[3-(Acetylthio)-(2S)-methylpropionyl]-L-proline;1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline;Acetylcaptopril

CAS NO.：64806-05-9

Empirical Formula: C18H28N2O6S2

Molecular Weight: 432.55

MDL number: MFCD08063643

PRODUCT Properties

• Melting point: 224-226°C
• Boiling point: 714.8±60.0 °C(Predicted)
• Density: 1.383±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer
• solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)
• form: Solid
• pka: 3.29±0.20(Predicted)
• color: White to Off-White
• Major Application: pharmaceutical; pharmaceutical small molecule
• InChI: 1S/C18H28N2O6S2/c1-11(15(21)19-7-3-5-13(19)17(23)24)9-27-28-10-12(2)16(22)20-8-4-6-14(20)18(25)26/h11-14H,3-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,12?,13+,14+/m1/s1
• InChIKey: ZWKRXBCJAUKDCI-KRCVMZOZSA-N

Description and Uses

Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID₅₀ = 0.231 mg/kg, i.v.).

Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.

Safety

• WGK Germany: 3
• HS Code: 2933999552
• Storage Class: 11 - Combustible Solids