Damnacanthal , 98% , 477-84-9
Synonym(s):
3-Hydroxy-1-methoxyanthraquinone-2-aldehyde;Damnacanthal - CAS 477-84-9 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2157.60 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 218～219℃ |
| Boiling point: | 531.9±50.0 °C(Predicted) |
| Density | 1.461±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 7 mg/ml) |
| pka | 5.26±0.20(Predicted) |
| form | Pale orange solid. |
| color | Yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChI | 1S/C16H10O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-7,18H,1H3 |
| InChIKey | IPDMWUNUULAXLU-UHFFFAOYSA-N |
| SMILES | O(C)c1c2c(cc(c1C=O)O)C(=O)c3c(cccc3)C2=O |
Description and Uses
Damnacanthal (477-84-9) is a potent inhibitor of p56lck?tyrosine kinase activity (IC50?= 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn?and p60src?tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases.1?Mobilizes intracellular Ca2+?in dermal fibroblasts.2?Inhibits LIM-kinase, impairing cell migration and invasion.3?A potent inhibitor of angiogenesis.4?Inhibits mast cell activation.5
Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity. Damnacanthal is used in the treatment of inflammatory-related diseases.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| WGK Germany | WGK 1 |
| Storage Class | 11 - Combustible Solids |
