Etifoxine , ≥99% , 21715-46-8

CAS NO.：21715-46-8

Empirical Formula: C17H17ClN2O

Molecular Weight: 300.78

MDL number: MFCD00868190

PRODUCT Properties

• Melting point: 90-92℃
• Boiling point: 421.2±55.0 °C(Predicted)
• Density: 1.1716 (rough estimate)
• vapor pressure: 0-1Pa at 20-25℃
• refractive index: 1.5800 (estimate)
• storage temp.: Store at -20°C
• solubility: DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM); DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM); DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM); Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM)
• form: Solid:particulate/powder
• pka: 4.89±0.40(Predicted)
• color: Light yellow to yellow
• LogP: 4.09-4.52 at 21-25℃ and pH7

Description and Uses

Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.1 It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.2 It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.3 Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.4 It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.2 Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant.5WARNING This product is not for human or veterinary use.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H401-H302
• Precautionary statements: P264-P270-P301+P312-P330-P501-P273-P501
• Toxicity: LD50 orally in mice: 12 g/kg (Hoffmann)