Etifoxine , ≥99% , 21715-46-8
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB711.20 | In Stock |
|
| 10mg | RMB734.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 90-92℃ |
| Boiling point: | 421.2±55.0 °C(Predicted) |
| Density | 1.1716 (rough estimate) |
| vapor pressure | 0-1Pa at 20-25℃ |
| refractive index | 1.5800 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM) DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM) |
| pka | 4.89±0.40(Predicted) |
| form | Solid:particulate/powder |
| color | Light yellow to yellow |
| LogP | 4.09-4.52 at 21-25℃ and pH7 |
Description and Uses
Etifoxine is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors.1 It selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM. Etifoxine inhibits binding of the GABAA receptor agonist muscimol in rat corticol membranes with a Kd value of 23 nM in a radioligand binding assay.2 It increases NGF-induced neurite outgrowth in PC12 cells when used at a concentration of 20 µM.3 Etifoxine (12.5 mg/kg, i.p.) increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice, indicating anxiolytic-like activity.4 It increases the seizure threshold in a mouse model of seizures induced by picrotoxin (Item No. 20771) with a minimum effective dose (MED) of 75 mg/kg.2 Etifoxine (50 mg/kg, i.p.) also increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant.5WARNING This product is not for human or veterinary use.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H401-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P501 |
| Toxicity | LD50 orally in mice: 12 g/kg (Hoffmann) |
| REACH Registrations | Active |
