2-Flurbiprofen , 98% , 51543-40-9
Synonym(s):
(R)-2-Flurbiprofen;Tarenflurbil
CAS NO.：51543-40-9
Empirical Formula: C15H13FO2
Molecular Weight: 244.26
MDL number: MFCD00869714
EINECS: 257-264-7
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB72.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 110-113 °C(lit.) |
| Boiling point: | 376.2±30.0 °C(Predicted) |
| Density | 1.199±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml |
| pka | 4.14±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to off-white |
| InChI | InChI=1/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/s3 |
| InChIKey | SYTBZMRGLBWNTM-JQHDBZEONA-N |
| SMILES | C1(C=CC([C@@H](C)C(=O)O)=CC=1F)C1=CC=CC=C1 |&1:4,r| |
Description and Uses
(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.
(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.
