M3344335
JNJ-38877605 , 99% , 943540-75-8
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB361.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Density | 1.50 |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥3.25 mg/mL in EtOH with ultrasonic |
| form | Powder |
| pka | 3.92±0.10(Predicted) |
| color | Off-white to light yellow |
| CAS DataBase Reference | 943540-75-8 |
Description and Uses
JNJ-38877605 is a potent inhibitor of c-Met catalytic activity. Selective over other tyrosine and serine-threonine kinases (600-fold selectivity). Ability to block constitutive or HGF-stimulated phosphorylation of c-Met demonstrated in vitro. JNJ 38877605 reduces radiation-induced invasion, apoptosis and proliferation of cancer cells in vitro.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319-H317 |
| Precautionary statements | P261-P264-P272-P280-P302+P352-P305+P351+P338-P333+P313-P321-P337+P313-P363-P501 |
