LY223982 , ≥99% , 117423-74-2

CAS NO.：117423-74-2

Empirical Formula: C30H30O7

Molecular Weight: 502.55

MDL number:

PRODUCT Properties

• Melting point: 151-152 °C
• Boiling point: 753.8±60.0 °C(Predicted)
• Density: 1.235±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer
• solubility: Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly)
• form: A crystalline solid
• pka: 3.81±0.10(Predicted)
• color: White to off-white

Description and Uses

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT₁ receptor antagonist. It inhibits the specific binding of radiolabeled-LTB₄ to isolated human neutrophils with an IC₅₀ value of 13.2 nM. LY223982 inhibits the leukotriene B₄ (LTB₄)-induced aggregation of guinea pig and human neutrophils with IC₅₀ values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB₄ to human BLT₁ or BLT₂ expressed in CHO cells.

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.