PRODUCT Properties
| storage temp. | Store at RT |
| solubility | Soluble in DMSO |
| form | Yellow solid |
| color | Light yellow to yellow |
| InChI | 1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H |
| InChIKey | GCHPUOHXXCNSQL-UHFFFAOYSA-N |
| SMILES | O=C1C2=C(C3c4c(cccc4)C2c5c3cccc5)C(=O)C=C1 |
Description and Uses
NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.
INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs.
Safety
| WGK Germany | WGK 1 |
| Storage Class | 11 - Combustible Solids |
