D-Methorphanhydrobromide , 125-69-9

Synonym(s):
(9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide;Dextromethorphan hydrobromide monohydrate

CAS NO.：125-69-9

Empirical Formula: C18H26BrNO

Molecular Weight: 352.31

MDL number: MFCD00269810

EINECS: 204-750-1

Update time: 2022-07-08

PRODUCT Properties

Melting point:	125-127℃
alpha	D20 +27.6° (c = 1.5 in water)
pka	pKa 8.83(50% aq EtOH) (Uncertain)
form	Solid
Water Solubility	Soluble in water (40 mM), and alcohol (1:10).
EPA Substance Registry System	Morphinan, 3-methoxy-17-methyl-, hydrobromide (1:1),(9.alpha.,13.alpha.,14.alpha.)- (125-69-9)

Description and Uses

It is used as a potentially useful NMDA receptor agonist. it is usually used as central nervous antitussive, cough suppressant. This is one of the most popular ingredients in over-the-counter cold and cough medications. Dextromethorphan hydrobromide may be added to other preparations to help treat pain and a variety of other disturbances as well. It is used as a pharmaceutical raw material.

Safety

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312a-P330-P501a
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36/37
RIDADR	3249
HazardClass	6.1(b)
PackingGroup	III
Toxicity	cat,LD50,intravenous,19800ug/kg (19.8mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEASENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1207, 1972.