M4379235
Narciclasine , 99.9% , 29477-83-6
Synonym(s):
Narciclasine;Lycoricidinol;(2S-(2-alpha,3-beta,4-beta,4a-beta))-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one;3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one;Lycoricidin-A
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2800.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 250-252℃ |
| Boiling point: | 447.77°C (rough estimate) |
| Density | 1.85±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥10mg/mL |
| pka | 7.72±0.70(Predicted) |
| form | Solid |
| color | white to off-white |
| InChI | InChI=1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1 |
| InChIKey | LZAZURSABQIKGB-AEKGRLRDSA-N |
| SMILES | C1=C2[C@@]([H])(NC(=O)C3C2=CC2OCOC=2C=3O)[C@H](O)[C@H](O)[C@H]1O |
Description and Uses
Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 μM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts. Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.
Narciclasine is an antiproliferative and pro-apoptotic inducer.
