M4476035
NSC86429 , 98% , 5812-07-7
Synonym(s):
3-(4-Dimethylaminobenzylidenyl)-2-indolinone;3-[[(4-Dimethyl-amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB473.60 | In Stock |
|
| 5mg | RMB2131.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 225-232 °C |
| Boiling point: | 497.1±45.0 °C(Predicted) |
| Density | 1.219±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 30 mg/mL |
| form | Orange solid. |
| pka | 12.89±0.20(Predicted) |
| color | orange |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | 1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+ |
| InChIKey | UAKWLVYMKBWHMX-RVDMUPIBSA-N |
| SMILES | CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23 |
Description and Uses
SU-4312 (5812-07-7) is a potent selective inhibitor of VEGFR kinase (also known as Flk-1 and KDR). Inhibition of the activated kinase (IC50 = 0.4 μM) is 100-fold less than inhibition of the unactivated kinase (IC50 = 0.04 μM). SU-4312 also inhibits PDGFR kinase (IC50 = 19.4 μM).
SU 4312 is a vascular endothelial growth factor receptor KDR tyrosine kinase antagonist.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
