269390-77-4
Synonym(s):
;VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 - CAS 269390-77-4 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB1780.49 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 158-160 °C |
| Boiling point: | 441.3±45.0 °C(Predicted) |
| Density | 1.349±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml). |
| form | Off-white powder |
| pka | 12.95±0.70(Predicted) |
| color | Pale yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | 1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27) |
| InChIKey | BLAFVGLBBOPRLP-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1cc(ccc1)NC(=O)c2c(cccc2)NCc3ccncc3 |
Description and Uses
AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhibited at higher concentrations (IC50‘s 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.
AAL-993 is a VEGFR tyrosine kinase inhibitor that possess dual inhibition of VEGFR signaling and HIF-1α expression through ERK inhibition without affecting Akt phosphorylation.
Safety
| WGK Germany | WGK 2 |
| Storage Class | 11 - Combustible Solids |
