Triamcinolone , 98% , 124-94-7

Synonym(s):
9α-Fluoro-11β,16α,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione;9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;Fluoxyprednisolone

CAS NO.：124-94-7

Empirical Formula: C21H27FO6

Molecular Weight: 394.43

MDL number: MFCD00010477

EINECS: 204-718-7

PRODUCT Properties

• Melting point: 262-263 °C(lit.)
• alpha: 69 º (c=2, DMF)
• Boiling point: 587.5±50.0 °C(Predicted)
• Density: 1.1703 (estimate)
• storage temp.: 2-8°C
• solubility: DMF: soluble20 mg/mL
• pka: 11.57±0.70(Predicted)
• form: Solid
• color: Crystals
• optical activity: [α]25/D +69°, c = 2 in DMF
• Water Solubility: 79.99mg/L(25 ºC)
• Merck: 9595
• InChIKey: GFNANZIMVAIWHM-OBYCQNJPSA-N
• CAS DataBase Reference: 124-94-7(CAS DataBase Reference)
• NIST Chemistry Reference: Triamcinolone(124-94-7)
• EPA Substance Registry System: Triamcinolone (124-94-7)

Description and Uses

A natural extension of corticoid research involved examination of compounds containing both a 9α-fluoro group and a double bond between positions 1 and 2. Triamcinolone (9-fluoro-11β, 16α, 17, 21-tetrahydroxypregna- 1,4-diene-3,20-dione), introduced in 1958, combines the structural features of a ?1 -corticoid and a 9α-fluoro corticoid. As mentioned previously, the 9α-fluoro group increases the anti-inflammatory potency, but it also markedly increases the mineralocorticoid potency. This is undesirable if the drug is to be used internally for the treatment of rheumatoid arthritis. By inserting a 16α-hydroxy group into the molecule, one can decrease the mineralocorticoid activity.

A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H351
• Precautionary statements: P280
• Hazard Codes: Xn
• Risk Statements: 40
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: TU3850000
• HS Code: 2937220000
• Hazardous Substances Data: 124-94-7(Hazardous Substances Data)
• Toxicity: LD50 subcutaneous in mouse: > 4gm/kg