Triamcinolone acetonide , 99% , 76-25-5

Synonym(s):
9α-Fluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide;9α-Fluoro-16α-hydroxyprednisolone 16α,17α-acetonide;Triamcinolone acetonide

CAS NO.：76-25-5

Empirical Formula: C24H31FO6

Molecular Weight: 434.5

MDL number: MFCD00056834

EINECS: 200-948-7

PRODUCT Properties

• Melting point: 274-278°C (dec.)
• alpha: D23 +109° (c = 0.75 in chloroform)
• Boiling point: 576.9±50.0 °C(Predicted)
• Density: 1.1517 (estimate)
• refractive index: 1.5980 (estimate)
• storage temp.: Refrigerator
• solubility: Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
• pka: 12.87±0.10(Predicted)
• form: Solid
• color: White to Off-White
• Water Solubility: Soluble in DMSO or ethanol. Slightly soluble in water.
• Merck: 9596
• BCS Class: 4
• Stability: Combustible. Incompatible with strong oxidizing agents.
• InChIKey: YNDXUCZADRHECN-JNQJZLCISA-N
• NIST Chemistry Reference: Triamcinolone acetonide(76-25-5)
• EPA Substance Registry System: Triamcinolone acetonide (76-25-5)

Description and Uses

Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H360
• Precautionary statements: P201-P202-P264-P270-P301+P312-P308+P313
• Hazard Codes: T
• Risk Statements: 61
• Safety Statements: 53-45
• WGK Germany: 3
• RTECS: TU3920000
• TSCA: TSCA listed
• HS Code: 29372290
• Toxicity: LD50 oral in mouse: 5gm/kg