Loganicacid , Analysis of control products, 98% , 22255-40-9

Synonym(s):
Loganate

CAS NO.：22255-40-9

Empirical Formula: C16H24O10

Molecular Weight: 376.36

MDL number: MFCD00017417

EINECS: 244-875-9

PRODUCT Properties

• Boiling point: 646.3±55.0 °C(Predicted)
• Density: 1.60±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in methan
• form: powder
• pka: 4.55±0.70(Predicted)
• color: White-beige
• LogP: -2.411 (est)

Description and Uses

Loganic acid is an iridoid glycoside that has been found in C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties. Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells. It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml. Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet. It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model.

Loganic Acid is found to be present in both the fermented fruits and brines. Exhibits antioxidant activity.

Safety

• WGK Germany: 3