2-(2-(2-Hydroxyethoxy)ethoxy)ethyl4-methylbenzenesulfonate , 95% , 77544-68-4

CAS NO.：77544-68-4

Empirical Formula: C13H20O6S

Molecular Weight: 304.36

MDL number: MFCD18433414

PRODUCT Properties

• Boiling point: 460.0±35.0 °C(Predicted)
• Density: 1.234±0.06 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: Ethanol: 100 mg/mL (328.56 mM); DMSO: 100 mg/mL (328.56 mM and warming)
• pka: 14.36±0.10(Predicted)
• form: Solid-Liquid Mixture
• color: Colorless to light yellow
• Water Solubility: Water: 10 mg/mL (32.86 mM)
• InChI: InChI=1S/C13H20O6S/c1-12-2-4-13(5-3-12)20(15,16)19-11-10-18-9-8-17-7-6-14/h2-5,14H,6-11H2,1H3
• InChIKey: RSUCRUOTLCQWFX-UHFFFAOYSA-N
• SMILES: C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCOCCO

Description and Uses

PEG3-Tos is a PEG linker containing a hydroxyl group and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338