97% , 77544-60-6

Synonym(s):
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluene-4-sulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluenesulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl tosylate;Monotosylated tetraethylene glycol

CAS NO.：77544-60-6

Empirical Formula: C15H24O7S

Molecular Weight: 348.41

MDL number: MFCD22056303

PRODUCT Properties

• Boiling point: 492.5±40.0 °C(Predicted)
• Density: 1.202 g/mL at 25 °C
• refractive index: n20/D1.507
• Flash point: >110℃
• storage temp.: 2-8°C
• solubility: Soluble in Water, DMSO, DCM, DMF
• form: Oil
• pka: 14.36±0.10(Predicted)
• color: Colourless
• InChI: InChI=1S/C15H24O7S/c1-14-2-4-15(5-3-14)23(17,18)22-13-12-21-11-10-20-9-8-19-7-6-16/h2-5,16H,6-13H2,1H3
• InChIKey: FGDJUEZBMFELRW-UHFFFAOYSA-N
• SMILES: C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCOCCOCCO

Description and Uses

PEG5-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

Safety

• Symbol(GHS): GHS05,GHS06
• Signal word: Danger
• Hazard statements: H301-H314
• Precautionary statements: P270-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338
• Hazard Codes: T,Xi
• Risk Statements: 25-34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2927 8(6.1) / PGII
• WGK Germany: 3