Simvastatinhydroxyacidsodium , ≥98% , 101314-97-0
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB1624.00 | In Stock |
|
| 5mg | RMB4000.00 | In Stock |
|
| 25mg | RMB4144.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >122°C (dec.) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | White powder solid. |
| color | White to Pale Beige |
| Stability: | Hygroscopic |
| InChIKey | FYSMQCWXGBXWLB-AIZTUWQCNA-N |
| SMILES | O([C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@@]12[H])C(=O)C(C)(C)CC.[NaH] |&1:1,3,9,11,14,17,23,r| |
Description and Uses
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-κB activation (IC50 = ~13 μM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.
Simvastatin Hydroxy Acid Sodium Salt is a metabolite of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H303-H361 |
| Precautionary statements | P201-P202-P280-P312-P405-P501 |
