HCToxin(ToxinI(Helminthosporiumcarbonum)) , 98% , 83209-65-8

CAS NO.：83209-65-8

Empirical Formula: C21H32N4O6

Molecular Weight: 436.51

MDL number: MFCD00133388

PRODUCT Properties

• Boiling point: 819.2±65.0 °C(Predicted)
• Density: 1.28±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 10 mg/ml; Methanol: 10 mg/ml
• pka: 13.33±0.70(Predicted)
• form: lyophilized powder
• color: Off-white to light yellow
• InChI: 1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)
• InChIKey: GNYCTMYOHGBSBI-UHFFFAOYSA-N
• SMILES: CC1NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCCCC(=O)C3CO3)NC1=O

Description and Uses

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300
• Precautionary statements: P264-P301+P310
• PPE: Eyeshields, Gloves, type N95 (US)
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Storage Class: 6.1B - Non-combustible acute toxic Cat. 1 and 2; very toxic hazardous materials
• Hazard Classifications: Acute Tox. 2 Oral