HCToxin(ToxinI(Helminthosporiumcarbonum)) , 98% , 83209-65-8

CAS NO.：83209-65-8

Empirical Formula: C21H32N4O6

Molecular Weight: 436.51

MDL number: MFCD00133388

PRODUCT Properties

• Boiling point: 819.2±65.0 °C(Predicted)
• Density: 1.28±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 10 mg/ml; Methanol: 10 mg/ml
• pka: 13.33±0.70(Predicted)
• form: lyophilized powder
• color: Off-white to light yellow

Description and Uses

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300
• Precautionary statements: P264-P301+P310
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3