O-DesmethylMetoprolol , 98% , 62572-94-5

CAS NO.：62572-94-5

Empirical Formula: C14H23NO3

Molecular Weight: 253.34

MDL number:

PRODUCT Properties

• Melting point: 70-720C
• Boiling point: 424.6±40.0 °C(Predicted)
• Density: 1.085±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer
• solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
• form: Solid
• pka: 13.88±0.20(Predicted)
• color: White to Off-White
• InChI: InChI=1S/C14H23NO3/c1-11(2)15-9-13(17)10-18-14-5-3-12(4-6-14)7-8-16/h3-6,11,13,15-17H,7-10H2,1-2H3
• InChIKey: CUKXSBOAIJILRY-UHFFFAOYSA-N
• SMILES: C1(CCO)=CC=C(OCC(O)CNC(C)C)C=C1

Description and Uses

O-Desmethyl metoprolol is the major active metabolite of the β₁-adrenergic receptor blocker metoprolol . It is formed by metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6 in vivo.

O-Desmethyl Metoprolol (Metoprolol EP Impurity H) is a metabolite of Metoprolol.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P330-P501
• Toxicity: LD50 intravenous in dog: 150mg/kg