(±)-Cromakalim(BRL34915) , 98% , 94470-67-4

Synonym(s):
(±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol

CAS NO.：94470-67-4

Empirical Formula: C16H18N2O3

Molecular Weight: 286.33

MDL number: MFCD00133201

Pack Size	Price	Stock	Quantity
10mg	RMB1865.60	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	242-244°C
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
form	solid
color	Off-white
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI	1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
InChIKey	TVZCRIROJQEVOT-CABCVRRESA-N
SMILES	CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N

Description and Uses

(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-K_ir6, that displays anti-ischemic (EC₂₅ = 8.9 μM) and cardioprotective (IC₅₀ = 0.03 μM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K⁺ channel openers with clinical relevance.

Cromakalim has been used:

as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.