EMI1(EGFRMaMTHInhibitor1) , 98% , 35773-42-3

CAS NO.：35773-42-3

Empirical Formula: C20H18N2O3

Molecular Weight: 334.37

MDL number:

EINECS: 252-721-7

PRODUCT Properties

• Melting point: 185-186 °C(Solv: N,N-dimethylformamide (68-12-2))
• Boiling point: 551.0±60.0 °C(Predicted)
• Density: 1.284±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 2mg/mL, clear
• form: Solid
• pka: 2.94±0.20(Predicted)
• color: Light yellow to yellow
• InChI: 1S/C20H18N2O3/c1-3-22(4-2)14-10-9-13-11-15(20(23)25-18(13)12-14)19-21-16-7-5-6-8-17(16)24-19/h5-12H,3-4H2,1-2H3
• InChIKey: UJOQSHCJYVRZKJ-UHFFFAOYSA-N
• SMILES: N(CC)(CC)c1cc2[o][c](c(cc2cc1)c3nc4c([o]3)cccc4)=O
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)- (35773-42-3)

Description and Uses

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].

Safety

• WGK Germany: WGK 3
• TSCA: TSCA listed
• Storage Class: 11 - Combustible Solids