M8394155
2''-C-Methyladenosine , ≥95% , 15397-12-3
| Pack Size | Price | Stock | Quantity |
| 50mg | RMB896.00 | In Stock |
|
| 250mg | RMB2688.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 643.4±65.0 °C(Predicted) |
| Density | 1.89 |
| storage temp. | Store at -20°C |
| solubility | DMF: 5 mg/mL; DMSO: 20 mg/mL; PBS (pH 7.2): 10 mg/mL |
| form | A crystalline solid |
| pka | 13.18±0.70(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C11H15N5O4/c1-11(19)7(18)5(2-17)20-10(11)16-4-15-6-8(12)13-3-14-9(6)16/h3-5,7,10,17-19H,2H2,1H3,(H2,12,13,14)/t5-,7-,10-,11-/m1/s1 |
| InChIKey | PASOFFRBGIVJET-YRKGHMEHSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@](C)(O)[C@@H]1O |
Description and Uses
2′-C-Methyladenosine has been shown to inhibit HCV RNA replication in the absence of cytotoxicity. The corresponding triphosphates were shown to be potent, competitive inhibitors of NS5B-catalyzed reactions in vitro.
2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2].
