AZ960 , 99% , 905586-69-8

CAS NO.：905586-69-8

Empirical Formula: C18H16F2N6

Molecular Weight: 354.36

MDL number: MFCD16621127

PRODUCT Properties

• Boiling point: 515.2±50.0 °C(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: Soluble in DMSO
• form: crystalline solid
• pka: 13.42±0.10(Predicted)
• color: Light yellow to yellow
• InChI: 1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1
• InChIKey: SUNXHXDJOIXABJ-NSHDSACASA-N
• SMILES: Fc1c(nc(c(c1)C#N)N[C@@H](C)c3ccc(cc3)F)Nc2[nH]nc(c2)C

Description and Uses

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. AZ 960 inhibits JAK2 with a K_i value of 0.45 nM in vitro. It can decrease STAT3/5 phosphorylation and inhibit cell proliferation in a SET-2 human megakaryoblastic cell line that is heterozygous for the JAK2 V617F mutation with a GI₅₀ value of 33 nM. AZ 960 can also induce apoptosis in human T cell lymophotropic virus type 1-infected (IC₅₀ = ~1 μM), which corresponds to a downregulation of phosphorylated forms of JAK2 and Bcl-2 family proteins.

AZ-960 Tyrosine Kinase inhibitor is useful for studying effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the Human JAK2 V617F Cell Line SET-2.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids