XAV-939 , ≥98% , 284028-89-3

Synonym(s):
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

CAS NO.：284028-89-3

Empirical Formula: C14H11F3N2OS

Molecular Weight: 312.31

MDL number: MFCD00106866

EINECS: 687-302-1

PRODUCT Properties

• Boiling point: 429.3±55.0 °C(Predicted)
• Density: 1.5
• Flash point: 213.4℃
• storage temp.: room temp
• solubility: DMSO: soluble5mg/mL, clear
• form: powder
• pka: 0.23±0.20(Predicted)
• color: white to beige
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
• InChI: 1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
• InChIKey: KLGQSVMIPOVQAX-UHFFFAOYSA-N
• SMILES: FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2

Description and Uses

XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).? Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1? XAV-939 robustly induces cardiomyogenesis of stem cells.2? Cell permeable

A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H319
• Precautionary statements: P301+P310-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 25-36
• Safety Statements: 26-45-26/45
• RIDADR: UN 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• HS Code: 29349990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral