ARRY-162 , 98% , 606143-89-9

CAS NO.：606143-89-9

Empirical Formula: C17H15BrF2N4O3

Molecular Weight: 441.23

MDL number: MFCD22124525

PRODUCT Properties

• Melting point: >203oC (dec.)
• Density: 1.67
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to at least 25 mg/ml)
• pka: 14.20±0.10(Predicted)
• form: solid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChI: InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
• InChIKey: ACWZRVQXLIRSDF-UHFFFAOYSA-N
• SMILES: C1N(C)C2=CC(C(NOCCO)=O)=C(NC3=CC=C(Br)C=C3F)C(F)=C2N=1

Description and Uses

Binimetinib (606143-89-9) is a potent (IC50= 12 nM) and selective allosteric inhibitor of MEK1/2.1,2Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited success as monotherapy but has shown promise in combination with other chemotherapeutic agents.3-5

MEK 162 is a MEK1/2 inhibitor allowing it to be a effective anti-cancer medication.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360-H362
• Precautionary statements: P201-P260-P263-P264-P270-P308+P313
• HS Code: 2933998090
• REACH Registrations: Inactive