3,5-Dimethyladamantan-1-amine , 97% , 19982-08-2

CAS NO.：19982-08-2

Empirical Formula: C12H21N

Molecular Weight: 179.3

MDL number: MFCD02114015

EINECS: 690-724-9

PRODUCT Properties

• Melting point: 258 °C
• Boiling point: 239.8±8.0 °C(Predicted)
• Density: 1.046
• refractive index: nD25 1.4941
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: Chloroform (Slightly), DMSO (Slightly)
• form: Solid
• pka: 10.79±0.60(Predicted)
• color: Colorless Oil to Off-White Waxy
• BCS Class: 1?
• InChI: InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
• InChIKey: BUGYDGFZZOZRHP-UHFFFAOYSA-N
• SMILES: C12(N)CC3(C)CC(CC(C)(C3)C1)C2
• CAS DataBase Reference: 19982-08-2(CAS DataBase Reference)

Description and Uses

Memantine is a potent antagonist of the N-methyl-D-aspartate (NMDA) receptor. Experimentally, memantine inhibits and reverses the abnor-mal activity of a protein phosphatase (PP-2A) that leads to tauhyperphosphorylation and to neurofibrillary degeneration inAD. Memantine is effective and well toler-ated in patients with severe AD and wasapproved by the FDA for the treatment of moderate-to-severe AD.

Recent phase 3 clinical trials have shown that Memantine is an effective way of treatment of both mild and moderate-to-severe Alzheimer''s disease and possibly vascular dementia (multi-infarct dementia). Memantine’s method of action involves an uncompetitive, low-affinity, open-channel blocker; it enters the receptor-associated ion channel preferentially when it is excessively open, and, most importantly, its off-rate is relatively fast so that it does not substantially accumulate in the channel to interfere with normal synaptic transmission.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P330-P501
• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 19982-08-2(Hazardous Substances Data)