S0873549
funnelcapacity500?mL,joint:ST/NS29/32,glasskey,graduated:no
Synonym(s):
(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
| Pack Size | Price | Stock | Quantity |
| 2ea | RMB1935.31 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 148-152 °C(lit.) |
| Boiling point: | 508.0±50.0 °C(Predicted) |
| Density | 1.125±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL |
| pka | 13.88±0.20(Predicted) |
| form | solid |
| color | pale yellow |
| optical activity | [α]25/D +16°, c = 1 in 1 M HCl |
| InChI | InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m1/s1 |
| InChIKey | METKIMKYRPQLGS-GFCCVEGCSA-N |
| SMILES | C1(CC(N)=O)=CC=C(OC[C@H](O)CNC(C)C)C=C1 |
Description and Uses
(+)-Atenolol is an enantiomer of the β1-adrenergic receptor (β1-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.
less active enantiomer
Safety
| WGK Germany | 3 |
