Caspase-1SubstrateVI,Fluorogenic-CAS219137-85-6-Calbiochem , Fluorogeniccaspase-1substrate. , 219137-85-6

Synonym(s):
Ac-YVAD-AFC;Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem;Z-YVAD-AFC

CAS NO.：219137-85-6

Empirical Formula: C33H36F3N5O10

Molecular Weight: 719.66

MDL number: MFCD01318881

PRODUCT Properties

• Melting point: >190°C (dec.)
• Boiling point: 1084.6±65.0 °C(Predicted)
• Density: 1.416±0.06 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: DMSO (Slightly), Methanol (Silghtly)
• pka: 4.09±0.10(Predicted)
• form: powder
• color: white
• InChIKey: GWKJISJKNKIJNP-DEQDFGQZSA-N
• SMILES: FC(F)(F)c1c2c([o][c](c1)=O)cc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)Cc3ccc(cc3)O)C(C)C)C)CC(=O)O

Description and Uses

Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.

N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research.

Safety

• WGK Germany: 3
• Storage Class: 11 - Combustible Solids