≥95%(HPLC) , 132489-69-1
CAS NO.：132489-69-1
Empirical Formula: C15H19N3O7
Molecular Weight: 353.33
MDL number: MFCD00145022
EINECS: 1533716-785-6
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1509.67 | In Stock |
|
| 10mg | RMB2814.15 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 172-175°C |
| Density | 1.53 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 35 mg/ml) |
| form | solid |
| pka | 11.85±0.70(Predicted) |
| color | White |
| BRN | 4274031 |
| Stability: | Moisture and Temperature Sensitive |
| InChIKey | PBLNJFVQMUMOJY-GJXDPMCDNA-N |
| SMILES | C1(=N/OC(=O)NC2C=CC=CC=2)/O[C@@H]([C@@H](O)[C@H](O)[C@H]/1NC(=O)C)CO |&1:13,14,16,18,r| |
Description and Uses
Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.
An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P302+P352-P362+P364 |
| WGK Germany | 3 |
| HS Code | 29329990 |
