≥95% , 176504-36-2
Synonym(s):
2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 250μG | RMB705.10 | In Stock |
|
| 1mg | RMB1927.41 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | 2-8°C |
| solubility | DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL |
| form | Orange-red solid |
| color | Orange to red |
| biological source | synthetic (organic) |
| Water Solubility | water: 10mg/mL DMSO: 20mg/mL |
| InChIKey | XRAMWNCMYJHGGH-UHFFFAOYSA-N |
| SMILES | Cl.CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 |
Description and Uses
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.
GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P301+P310 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| HS Code | 2933998090 |
| Storage Class | 11 - Combustible Solids |
