≥98%(HPLC) , 139290-65-6

Synonym(s):
(R)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol;MDL100907;Volinanserin

CAS NO.：139290-65-6

Empirical Formula: C22H28FNO3

Molecular Weight: 373.46

MDL number: MFCD00909060

PRODUCT Properties

• Melting point: 89-91°C
• Boiling point: 499.4±45.0 °C(Predicted)
• Density: 1.150±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥20mg/mL
• form: powder
• pka: 13.93±0.20(Predicted)
• color: off-white to light brown

Description and Uses

Volinanserin is a potent and selective antagonist of the serotonin receptor 5-HT_2A (K_i = 0.36-0.85 nM). It weakly binds 5-HT_2C, α₁-adrenergic, and sigma receptors (K_i = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and monoamine transporters. Volinanserin displays antipsychotic activity, attenuates impulsivity, and augments antidepressant effects in vivo.

Volinanserin is a serotonin receptor 5-HT2A antagonist; anti-psychotic.

Safety

• Symbol(GHS): GHS09
• Signal word: Warning
• Hazard statements: H400
• Precautionary statements: P273
• Hazard Codes: N
• Risk Statements: 50
• Safety Statements: 61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3