solid , 27536-56-7

Synonym(s):
4αPDD;4αPDD, PKC Activator I, Negative Control;4α-Phorbol 12-13-dicaprinate;4α-Phorbol-12,13-didecanoate - CAS 27536-56-7 - Calbiochem

CAS NO.：27536-56-7

Empirical Formula: C40H64O8

Molecular Weight: 672.93

MDL number: MFCD00036737

PRODUCT Properties

• storage temp.: -20°C
• solubility: DMSO: soluble
• form: solid
• color: white
• BRN: 2514324
• InChIKey: DGOSGFYDFDYMCW-OEFRVDPMSA-N
• SMILES: O([C@]21[C@H]([C@H]3[C@@]([C@H]4[C@@](CC(=C3)CO)(C(=O)C(=C4)C)O)([C@@H]([C@H]2OC(=O)CCCCCCCCC)C)O)C1(C)C)C(=O)CCCCCCCCC

Description and Uses

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:

• to study its effects on Madin-Darby canine kidney (MDCK) cells
• to study its effects on Ca²⁺ influx in mice fallopian tubal cells
• to study its effects on hind paw swelling in mice

Safety

• Symbol(GHS): GHS05,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300+H310+H330-H314-H317-H334-H351
• Precautionary statements: P201-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
• Hazard Codes: T+
• Risk Statements: 26/27/28-40-43
• Safety Statements: 36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• F: 8-10
• HazardClass: 6.1(b)
• PackingGroup: III
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2; very toxic hazardous materials
• Hazard Classifications: Acute Tox. 1 Dermal; Acute Tox. 1 Inhalation; Acute Tox. 2 Oral; Carc. 2; Resp. Sens. 1; Skin Corr. 1B; Skin Sens. 1