S9115114
solid , 91917-65-6
Synonym(s):
Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate;Ro15-4513
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB5494.78 | In Stock |
|
| 100mg | RMB18542.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| storage temp. | Desiccate at +4°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL |
| form | solid |
| color | tan |
| Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8mg/mL H2O: insoluble methanol: soluble |
| InChI | 1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 |
| InChIKey | CFSOJZTUTOQNIA-UHFFFAOYSA-N |
| SMILES | CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-] |
| CAS DataBase Reference | 91917-65-6 |
Description and Uses
Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors.
Ro 15-4513 is an alcohol antagonist.
Safety
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
