S9122014
≥94%(HPLC),(solidorpowder) , 59864-04-9
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1043.70 | In Stock |
|
| 25mg | RMB4010.16 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 201～203℃ |
| storage temp. | RT |
| solubility | DMSO: >25 mg/mL |
| form | solid |
| color | yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| InChI | 1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+ |
| InChIKey | MVGSNCBCUWPVDA-RQZCQDPDSA-N |
| SMILES | CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(C)(=O)=O |
Description and Uses
Sulindac sulfone (59864-04-9) is a metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases.1 Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells.2 Modulates beta-catenin mediated effects. 3
Sulindac Sulfone is an inhibitor of growth and inducer of apoptosis in cancer cell lines.
Safety
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
