S9150914
≥98%(HPLC) , 675576-98-4
Synonym(s):
Nutlin 3a;(-)-4-(4,5- bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one;(-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one;(-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one;(-)-Nutlin-3
CAS NO.：675576-98-4
Empirical Formula: C30H30Cl2N4O4
Molecular Weight: 581.49
MDL number: MFCD14636430
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB2561.82 | In Stock |
|
| 25mg | RMB10294.70 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Density | 1.36 |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear |
| form | White powder |
| pka | 14.35±0.20(Predicted) |
| color | white to beige |
| optical activity | [α]/D -140 to -155° (c=0.5, CDCl3) |
| InChIKey | BDUHCSBCVGXTJM-WUFINQPMSA-N |
| SMILES | N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@@H](C3=CC=C(Cl)C=C3)[C@H]2C2=CC=C(Cl)C=C2)=O)CC1=O |
Description and Uses
Nutlin-3 is a novel small-molecule antagonist of the human homolog of mouse double minute (MDM2) that binds MDM2 in the p53-binding pocket and activates the p53 signaling pathway.
Nutlin-3a has been used as a tumor suppressor p53(TP53) stabilizer and as an inhibitor of the mouse double minute 2 homolog (MDM2)–p53 interaction.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
