≥98%(HPLC) , 947303-87-9

Synonym(s):
4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-benzamide dihydrochloride;PF 429242 dihydrochloride

CAS NO.：947303-87-9

Empirical Formula: C25H35N3O2

Molecular Weight: 409.56

MDL number: MFCD21603814

PRODUCT Properties

• Boiling point: 562.2±50.0 °C(Predicted)
• Density: 1.11±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: H2O: soluble15mg/mL, clear
• pka: 9.47±0.10(Predicted)
• form: powder
• color: white to beige
• Water Solubility: H2O: 15mg/mL, clear
• InChI: 1S/C25H35N3O2/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3/h6-13,23,26H,4-5,14-19H2,1-3H3/t23-/m1/s1
• InChIKey: XKPJTOHUPQWSOJ-HSZRJFAPSA-N
• SMILES: N1C[C@@H](CC1)N(CCc3c(cccc3)OC)C(=O)c2ccc(cc2)CN(CC)CC

Description and Uses

PF 429242 is a novel subtilisin kexin isozyme-1/site-1 (SKI-1/S1P) protease inhibitor. PF 429242 is a sterol regulatory element-binding protein1 (SREBP1) inhibitor and has been shown to decrease pancreatic cancer cell viability and proliferation.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H315-H319-H335-H410
• Precautionary statements: P273-P302+P352-P305+P351+P338
• target organs: Respiratory system
• Hazard Codes: Xi,N
• Risk Statements: 36/37/38-50
• Safety Statements: 26-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Acute 1; Aquatic Chronic 1; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3