≥98%(HPLC) , 882257-11-6

Synonym(s):
1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone; 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone

CAS NO.：882257-11-6

Empirical Formula: C12H7Cl2NO3S2

Molecular Weight: 348.22

MDL number: MFCD00123202

PRODUCT Properties

• Boiling point: 452.4±45.0 °C(Predicted)
• Density: 1.60±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: soluble10mg/mL, clear
• form: powder
• color: light yellow to dark yellow
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChI: 1S/C12H7Cl2NO3S2/c1-6(16)10-5-8(15(17)18)12(20-10)19-9-4-2-3-7(13)11(9)14/h2-5H,1H3
• InChIKey: LKZLGMAAKNEGCH-UHFFFAOYSA-N
• SMILES: [s]1c(c(cc1C(=O)C)[N+](=O)[O-])Sc2c(c(ccc2)Cl)Cl

Description and Uses

P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable

P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H413
• Precautionary statements: P273-P301+P310+P330
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 3 Oral; Aquatic Chronic 4