S9218214
≥98%(HPLC) , 471-05-6
Synonym(s):
(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one;Zerumbone (6CI,7CI)
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB783.23 | In Stock |
|
| 50mg | RMB2920.87 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 67-69℃ |
| Boiling point: | 321.6±42.0 °C(Predicted) |
| Density | 0.887±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | white to off-white |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+ |
| InChIKey | GIHNTRQPEMKFKO-SKTNYSRSSA-N |
| SMILES | C1(=O)C=CC(C)(C)CC=C(C)CCC=C1C |c:8,t:2,13| |
| LogP | 4.168 (est) |
Description and Uses
Zerumbone (471-05-6) is a natural sesquiterpene ketone isolated from Zingiber sp. Potentiates TRAIL-induced apoptosis via upregulation of death receptor DR4 and DR5 expression. Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells but has no cytotoxic effect on normal cells. Cell permeable.
Zerumbone has been used:
- for liquid chromatography with mass spectrometry (LC-MS-MS)
- to investigate its potential application in the prevention
- treatment of esophageal squamous cell carcinomas (ESCC)
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H317-H400 |
| Precautionary statements | P273-P280-P302+P352 |
| Hazard Codes | Xi,N |
| Risk Statements | 43-50 |
| Safety Statements | 36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
