Almotriptan Malate , >98.0%(HPLC) , 181183-52-8

Synonym(s):
3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indole malate;PNU 180638

CAS NO.：181183-52-8

Empirical Formula: C21H31N3O7S

Molecular Weight: 469.55

MDL number: MFCD00927104

EINECS: 815-382-1

PRODUCT Properties

• Melting point: 170-172°C
• storage temp.: 2-8°C
• solubility: Basic Alcohol (Very Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
• form: powder
• color: white to beige
• Water Solubility: H2O: 10mg/mL, clear

Description and Uses

Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT_1B and 5-HT_1D (IC₅₀s = 12 and 13 nM, respectively, in a radioligand binding assay). It is selective for human 5-HT_1B and 5-HT_1D receptors over rat 5-HT_1A and human 5-HT_2A and 5-HT₄ receptors (IC₅₀s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC₅₀ = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED₁₀₀ = 11 μg/kg, i.v.) without increasing blood pressure or heart rate. Formulations containing almotriptan have been used in the treatment of migraine headaches.

anti-migraine agent

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H312-H332
• Precautionary statements: P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501
• HS Code: 2935904000