Etomidate , >98.0%(GC) , 33125-97-2

Synonym(s):
(R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester;Amidate;R16659

CAS NO.：33125-97-2

Empirical Formula: C14H16N2O2

Molecular Weight: 244.29

MDL number: MFCD00869295

EINECS: 251-385-9

Update time: 2022-07-08

PRODUCT Properties

Melting point:	72-74°C
alpha	D20 +66° (c = 1 in ethanol)
Boiling point:	160-162 °C(Press: 1 Torr)
Density	1.11±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >10 mg/mL
form	powder
pka	pKa 4.24(H2O t=25.0) (Uncertain)
color	white
Merck	14,3881
CAS DataBase Reference	33125-97-2(CAS DataBase Reference)
NIST Chemistry Reference	Etomidate(33125-97-2)

Description and Uses

Etomidate , ethyl (R)-(+)-1(α- methylbenzyl)-imidazole-5-carboxylate, Mr 224.28, is a white to yellowish crystalline or amorphous powder. It is insoluble in water at pH 7, but soluble in acidic aqueous solutions at pH<3. Etomidate is soluble in propylene glycol and readily soluble in alcohol.

Etomidate is a GABAA receptors agonist with short-acting sedative, hypnotic, and general anesthetic properties. It is a unique drug used for induction of general anesthesia and sedation. It is also a hypnotic. Hypnotic effect of Etomidate is strong , and its efficacy is about 12 times higher than thiopental, it has no analgesic effect.

Safety

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302-H400
Precautionary statements	P301+P312+P330
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS	NI4021500
HazardClass	9
PackingGroup	III
HS Code	29332900
Toxicity	LD50 in mice, rats (mg/kg): 29.5, 14.8-24.3 i.v. (Janssen)