Prostaglandin F2α , >95.0%(T) , 551-11-1
Synonym(s):
Prostaglandin F 2α - CAS 551-11-1 - Calbiochem
CAS NO.：551-11-1
Empirical Formula: C20H34O5
Molecular Weight: 354.49
MDL number: MFCD00135231
EINECS: 215-355-9
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB444.00 | In Stock |
|
| 10mg | RMB3036.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 25-35° |
| alpha | D25 +23.5° (c = 1 in tetrahydrofuran) |
| Boiling point: | 407.69°C (rough estimate) |
| Density | 1.0458 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| Flash point: | Not applicable |
| storage temp. | Store at -20°C |
| solubility | DMSO:100.0(Max Conc. mg/mL);282.1(Max Conc. mM) Water:100.0(Max Conc. mg/mL);282.1(Max Conc. mM) |
| pka | pKa 4.90(H2O,t=25±2,I=0.0，c<0.01,N2) (Uncertain) |
| form | powder to lump to clear liquid |
| color | White or Colorless to Almost white or Almost colorless |
| InChI | 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+ |
| InChIKey | PXGPLTODNUVGFL-JPYXJAOSNA-N |
| SMILES | C([C@H]1[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCCCC)O)/C=C\CCCC(=O)O |&1:1,2,4,6,9,r| |
| CAS DataBase Reference | 551-11-1(CAS DataBase Reference) |
Description and Uses
Prostaglandin F2α (PGF2α) is present in numerous species and has a widespread distribution. It can cause smooth muscle contraction in the vascular, bronchial, intestinal, and myometrial regions, and has potent luteolytic activity. PGF2α exerts its physiological effects through receptor mediation, with maximal ovine myometrial contraction being achieved at 125 nM PGF2α in vitro, and its receptor-mediated activity is most potent at 50-100 nM. Studies have also shown that PGF2α inhibits nitric oxide production in uterine tissue, enhances uterine contractility, and exhibits potent luteolytic activity. Furthermore, PGF2α functions as an activator of PGF2αR.
Prostaglandin F2α is one of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H360D |
| Precautionary statements | P201-P202-P264-P270-P301+P312-P308+P313 |
| WGK Germany | WGK 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Oral Repr. 1B |
| Hazardous Substances Data | 551-11-1(Hazardous Substances Data) |
| Toxicity | LD50 in rabbits (mg/kg): 2.5-5.0 i.v.; 2.5-5.0 i.m. (Fujita) |
