5-Amino-3-(trifluoromethyl)picolinonitrile , 98% , 573762-62-6

CAS NO.：573762-62-6

Empirical Formula: C7H4F3N3

Molecular Weight: 187.12

MDL number: MFCD17010171

EINECS: 815-137-9

PRODUCT Properties

• Boiling point: 362.2±42.0 °C(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• pka: -1.52±0.10(Predicted)
• Appearance: Off-white to yellow Solid
• InChI: InChI=1S/C7H4F3N3/c8-7(9,10)5-1-4(12)3-13-6(5)2-11/h1,3H,12H2
• InChIKey: WLMSCOVORZUSNW-UHFFFAOYSA-N
• SMILES: C1(C#N)=NC=C(N)C=C1C(F)(F)F

Description and Uses

5-Amino-3-(trifluoromethyl)picolinonitrile is one of the key intermediates of apalutamide (N-2). As a second-generation nonsteroidal androgen receptor inhibitor, apalutamide can prevent the binding of androgens to their receptors and block the translocation of androgen receptor (AR) into the nuclei of cancer cells; in addition, it can regulate androgen activity and inhibit the growth of cancer cells.

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE is a pyridine heterocyclic organic compound, which can be used as pharmaceutical intermediates.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301+H311+H331
• Precautionary statements: P260-P280-P311
• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: Ⅲ
• HS Code: 2933399990