BOP Reagent , 98% , 56602-33-6

Synonym(s):
Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphoniumhexafluorophosphate, Castro′s Reagent;BOP;BOP Reagent;Castros reagent

CAS NO.：56602-33-6

Empirical Formula: C12H22F6N6OP2

Molecular Weight: 442.29

MDL number: MFCD00011948

EINECS: 260-279-1

PRODUCT Properties

• Melting point: >130 °C (dec.)(lit.)
• Flash point: 138°C
• storage temp.: 2-8°C
• solubility: methanol: 25 mg/mL, clear
• form: Powder
• color: White to off-white
• Water Solubility: Soluble in methanol, acetone and dichloromethane. Insoluble in water.
• Sensitive: Moisture & Light Sensitive
• Decomposition: 138 ºC
• BRN: 4287025
• InChI: InChI=1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1
• InChIKey: MGEVGECQZUIPSV-UHFFFAOYSA-N
• SMILES: [P+5]([F-])([F-])([F-])([F-])([F-])[F-].[P+](N(C)C)(N(C)C)(N(C)C)ON1N=NC2C=CC=CC1=2
• CAS DataBase Reference: 56602-33-6(CAS DataBase Reference)

Description and Uses

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H228-H315-H335
• Precautionary statements: P210-P240-P241-P261-P264-P302+P352
• Hazard Codes: Xi,E,F
• Risk Statements: 37/38-44-36/37/38-11-2
• Safety Statements: 24/25-37/39-36-26-35-36/37/39
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• F: 8-10-21
• Hazard Note: Irritant
• HazardClass: 4.1
• PackingGroup: Ⅱ
• HS Code: 29339980
• Limited Quantities: 1.0 Kg (2.2 lbs)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)