Benzbromarone , Analysis standard , 3562-84-3
Synonym(s):
3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran
CAS NO.：3562-84-3
Empirical Formula: C17H12Br2O3
Molecular Weight: 424.08
MDL number: MFCD00078962
EINECS: 222-630-7
| Pack Size | Price | Stock | Quantity |
| 1G | RMB319.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 151° |
| Boiling point: | 514.1±50.0 °C(Predicted) |
| Density | 1.6211 (rough estimate) |
| refractive index | 1.6010 (estimate) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent). |
| pka | 4.66±0.25(Predicted) |
| form | Solid |
| color | White to Light yellow |
| Merck | 14,1065 |
| InChI | InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3 |
| InChIKey | WHQCHUCQKNIQEC-UHFFFAOYSA-N |
| SMILES | C(C1=CC(Br)=C(O)C(Br)=C1)(C1C2=CC=CC=C2OC=1CC)=O |
| CAS DataBase Reference | 3562-84-3(CAS DataBase Reference) |
| EPA Substance Registry System | Methanone, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)- (3562-84-3) |
Description and Uses
Benzbromarone,a non-competitive inhibitor of xanthine oxidase，is apotent uricosuric drug used in the treatment of gout.
Benzbromarone is a benzofuran derivative chemically related to amiodarone. It increases uric acid excretion by non-specificallyinhibiting its tubular reabsorption.
lt is used in patients with venous disorders to prevent,retard,or reverse varicose degenerative changes in the vessel wall.
Benzbromarone causes diarrhea (3-4% of patients), urate and oxalate stones,urinary sand,renal colic，and allergy in a small number of patients.Liver damage, which reverses after withdrawal, has been described (SEDA-18,108).
Coronarodilatator;Uric acid transport inhibitor
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | OB1804200 |
| HS Code | 2932.99.7000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in rat: 248mg/kg |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
