Trihexyphenidyl Hydrochloride , 98% , 52-49-3
Synonym(s):
(±)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride;Trihexyphenidyl hydrochloride
CAS NO.：52-49-3
Empirical Formula: C20H31NO.ClH
Molecular Weight: 337.93
MDL number: MFCD00058212
EINECS: 200-142-5
| Pack Size | Price | Stock | Quantity |
| 1G | RMB59.20 | In Stock |
|
| 5G | RMB221.60 | In Stock |
|
| 25G | RMB751.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | Free base, mp 114.3-115.0° |
| Density | 0.9801 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble |
| form | solid |
| color | white |
| Water Solubility | 670.9ug/L(22.5 ºC) |
| Merck | 14,9695 |
| Stability: | Stable at RT, Stable At Rt |
| InChI | InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H |
| InChIKey | QDWJJTJNXAKQKD-UHFFFAOYSA-N |
| SMILES | C(O)(CCN1CCCCC1)(C1CCCCC1)C1C=CC=CC=1.Cl |
| CAS DataBase Reference | 52-49-3(CAS DataBase Reference) |
Description and Uses
Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors. It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC50 = 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.
anticholinergic, antiparkinsonian
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | TN2625000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933399090 |
| Toxicity | TDLo orl-wmn: 800 mg/kg:BAH BJPYAJ 145,300,84 |
