4′-Bromopropiophenone , ≥99.0%(GC) , 10342-83-3

CAS NO.：10342-83-3

Empirical Formula: C9H9BrO

Molecular Weight: 213.07

MDL number: MFCD00000106

EINECS: 233-745-7

PRODUCT Properties

• Melting point: 45-47 °C(lit.)
• Boiling point: 138-140 °C14 mm Hg(lit.)
• Density: 1.3841 (rough estimate)
• refractive index: 1.5720 (estimate)
• Flash point: >230 °F
• storage temp.: Sealed in dry,Room Temperature
• solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol
• form: powder to crystal
• color: White to Almost white
• BRN: 1210311
• InChI: InChI=1S/C9H9BrO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6H,2H2,1H3
• InChIKey: UOMOSYFPKGQIKI-UHFFFAOYSA-N
• SMILES: C(C1=CC=C(Br)C=C1)(=O)CC
• CAS DataBase Reference: 10342-83-3(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(4-bromophenyl)-(10342-83-3)

Description and Uses

4'-Bromopropiophenone is used as a raw material for organic synthesis or as a pharmaceutical intermediate reagent. The 4′-Bromopropiophenone can be employed as a starting material for synthesising novel 5-substituted pyrazole derivatives via Suzuki-type coupling with alkenes. These derivatives function as potent CB1 antagonists exhibiting binding affinities comparable to SR 141716A, presenting potential as therapeutic agents for obesity.

4'-Bromopropiophenone is an electron-deficient aryl bromide that has the ability to self-polymerize using binary palladium catalyst. 4'-Bromopropiophenone is also used as a reagent in the synthesis of substituted 2-aminothiazoles (e.g. 2-Aminobenzothiazole [A593500]), compounds that are inhibitors of neuronal degeneration in patients with Alzheimer’s disease.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H317-H319-H335
• Precautionary statements: P280-P301+P312+P330-P302+P352-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 29147000