A1643250
ML141 , ≥98% , 71203-35-5
Synonym(s):
4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide;z;Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB345.60 | In Stock |
|
| 10mg | RMB639.20 | In Stock |
|
| 25mg | RMB1519.20 | In Stock |
|
| 50mg | RMB2959.20 | In Stock |
|
| 100mg | RMB5183.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 216 °C(Solv: ethanol (64-17-5)) |
| Boiling point: | 622.9±65.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL (warmed, clear solution) |
| pka | 10.39±0.10(Predicted) |
| form | Yellow-white solid |
| color | white to beige |
| InChI | 1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27) |
| InChIKey | QBNZBMVRFYREHK-UHFFFAOYSA-N |
| SMILES | NS(C1=CC=C(C=C1)N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)(=O)=O |
Description and Uses
ML 141 has been used:
- to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
- as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
- as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
- as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
