3-Chloropropionyl chloride , 96% , 625-36-5

CAS NO.：625-36-5

Empirical Formula: C3H4Cl2O

Molecular Weight: 126.97

MDL number: MFCD00000747

EINECS: 210-890-4

PRODUCT Properties

• Melting point: -32 °C
• Boiling point: 143-145 °C(lit.)
• Density: 1.33 g/mL at 25 °C(lit.)
• vapor pressure: 10.0 hPa
• refractive index: n20/D 1.457(lit.)
• RTECS: UC3934000
• Flash point: 146 °F
• storage temp.: Flammables area
• solubility: Chloroform, Ethyl Acetate
• form: liquid
• color: red-brown
• PH: <7 (H2O)
• explosive limit: 8.8-20.2%(V)
• Water Solubility: reacts
• Sensitive: Moisture Sensitive
• BRN: 635814
• Stability: Moisture Sensitive
• InChIKey: INUNLMUAPJVRME-UHFFFAOYSA-N
• CAS DataBase Reference: 625-36-5(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoyl chloride, 3-chloro-(625-36-5)
• EPA Substance Registry System: Propanoyl chloride, 3-chloro- (625-36-5)

Description and Uses

3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.

3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.

Safety

• Symbol(GHS): GHS05,GHS06
• Signal word: Danger
• Hazard statements: H302-H314-H330
• Precautionary statements: P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
• Hazard Codes: T+
• Risk Statements: 14-22-26-34-35-10
• Safety Statements: 23-26-36/37/39-45-38-16-8
• RIDADR: UN 3390 6.1/PG 1
• WGK Germany: 1
• F: 21
• Autoignition Temperature: 460°C
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: I
• HS Code: 29159080