Clomiphene citrate salt , 98%, a mixture , 50-41-9

Synonym(s):
2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine;Clomiphene citrate salt

CAS NO.：50-41-9

Empirical Formula: C32H36ClNO8

Molecular Weight: 598.08

MDL number: MFCD00058322

EINECS: 200-035-3

PRODUCT Properties

• Melting point: 116.5-118°C
• storage temp.: 2-8°C
• solubility: Slightly soluble in water, sparingly soluble in ethanol (96 per cent).
• form: Solid
• color: White to Off-White
• Water Solubility: Slightly soluble in water, methanol, chloroform (slightly), and DMSO (10 mM). Insoluble in ether.
• BCS Class: 3/1
• InChIKey: PYTMYKVIJXPNBD-OQKDUQJOSA-N
• SMILES: N(CC)(CC)CCOC1=CC=C(/C(/C2=CC=CC=C2)=C(\Cl)/C2=CC=CC=C2)C=C1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O
• CAS DataBase Reference: 50-41-9(CAS DataBase Reference)
• IARC: 3 (Vol. 21, Sup 7) 1987
• EPA Substance Registry System: Clomiphene citrate (50-41-9)

Description and Uses

Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol. It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively). Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360FD
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: T
• Risk Statements: 60-63
• Safety Statements: 53-36/37-45
• WGK Germany: 3
• RTECS: YE0875000
• HazardClass: IRRITANT
• HS Code: 2922190900
• Toxicity: LD50 oral in rat: 5750mg/kg