2-chloro-3-quinolinecarboxaldehyde , ≥98.0%(GC) , 73568-25-9

CAS NO.：73568-25-9

Empirical Formula: C10H6ClNO

Molecular Weight: 191.61

MDL number: MFCD00130079

PRODUCT Properties

• Melting point: 150 °C
• Boiling point: 335.8±22.0 °C(Predicted)
• Density: 1.364
• Flash point: Not applicable
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• form: powder to crystal
• pka: -1.31±0.50(Predicted)
• color: White to Light yellow to Green
• Sensitive: Air Sensitive
• InChI: 1S/C10H6ClNO/c11-10-8(6-13)5-7-3-1-2-4-9(7)12-10/h1-6H
• InChIKey: SDKQWXCBSNMYBN-UHFFFAOYSA-N
• SMILES: Clc1nc2ccccc2cc1C=O
• CAS DataBase Reference: 73568-25-9(CAS DataBase Reference)

Description and Uses

2-Chloroquinoline-3-carbaldehydes and their derivatives are recognized for their biological and pharmacological activities, including antimicrobial, anti-inflammatory, antimalarial, and antiviral properties. It serves as a precursor for Schiff base synthesis, reacting with 7-methyl-2-propyl-3H-benzoimidazole-5-carbohydrazide in ethanol/DMF at 50–55 °C followed by reflux at 85–90 °C to give the corresponding hydrazide Schiff base. Under Mg-Al hydrotalcite catalysis, 2-chloroquinoline-3-carbaldehyde reacts with nitromethane to afford threo (1S,2R)-1-(2-chloroquinoline-3-yl)-2-nitropropane-1-ol and 2-chloro-3-(2-nitrovinyl)quinoline[3-4].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P302+P352-P305+P351+P338
• target organs: Respiratory system
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HS Code: 29334900
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2; Skin Irrit. 2; STOT SE 3